全文获取类型
收费全文 | 957075篇 |
免费 | 69219篇 |
国内免费 | 1519篇 |
专业分类
耳鼻咽喉 | 13179篇 |
儿科学 | 24970篇 |
妇产科学 | 23658篇 |
基础医学 | 136101篇 |
口腔科学 | 28933篇 |
临床医学 | 82368篇 |
内科学 | 189549篇 |
皮肤病学 | 19693篇 |
神经病学 | 74133篇 |
特种医学 | 37809篇 |
外国民族医学 | 79篇 |
外科学 | 157270篇 |
综合类 | 18141篇 |
现状与发展 | 1篇 |
一般理论 | 235篇 |
预防医学 | 62474篇 |
眼科学 | 21720篇 |
药学 | 74562篇 |
4篇 | |
中国医学 | 2217篇 |
肿瘤学 | 60717篇 |
出版年
2018年 | 9694篇 |
2017年 | 7594篇 |
2016年 | 8397篇 |
2015年 | 9564篇 |
2014年 | 12906篇 |
2013年 | 18633篇 |
2012年 | 25825篇 |
2011年 | 26908篇 |
2010年 | 15867篇 |
2009年 | 15115篇 |
2008年 | 26194篇 |
2007年 | 27401篇 |
2006年 | 28161篇 |
2005年 | 27096篇 |
2004年 | 26249篇 |
2003年 | 25166篇 |
2002年 | 24705篇 |
2001年 | 55430篇 |
2000年 | 57125篇 |
1999年 | 47447篇 |
1998年 | 10668篇 |
1997年 | 9290篇 |
1996年 | 9398篇 |
1995年 | 9161篇 |
1994年 | 8515篇 |
1993年 | 7810篇 |
1992年 | 35925篇 |
1991年 | 34315篇 |
1990年 | 33048篇 |
1989年 | 32253篇 |
1988年 | 29277篇 |
1987年 | 28559篇 |
1986年 | 26614篇 |
1985年 | 25438篇 |
1984年 | 18016篇 |
1983年 | 15291篇 |
1982年 | 7875篇 |
1981年 | 6851篇 |
1979年 | 15918篇 |
1978年 | 10712篇 |
1977年 | 9134篇 |
1976年 | 7958篇 |
1975年 | 8728篇 |
1974年 | 10565篇 |
1973年 | 9948篇 |
1972年 | 9437篇 |
1971年 | 8952篇 |
1970年 | 8493篇 |
1969年 | 8013篇 |
1968年 | 7287篇 |
排序方式: 共有10000条查询结果,搜索用时 93 毫秒
1.
2.
Kazuya Inoue Naoki Suenaga Naomi Oizumi Hiroshi Yamaguchi Naoki Miyoshi Noboru Taniguchi Noriaki Matsumura Shuzo Morita Shimpei Kurata Yasuhito Tanaka 《Seminars in Arthroplasty》2022,32(2):252-257
BackgroundIn shoulder arthroplasty, bone resorption around the stem can lead to stem loosening and makes surgery difficult at the time of revision. Proximal bone resorption after reverse shoulder arthroplasty can cause instability because of a decrease of deltoid wrapping effect. As factors of the stem itself, such as stem coating, shape, length, and use of bone cement, may also affect bone resorption, a single-stem model should be used to compare bone resorptions between different pathologies and surgical procedures. However, to date, a few reports have compared these differences in detail using a single-stem model. Therefore, we investigated the prevalence and location of humeral bone resorption in a single-stem model.MethodsThe study included 100 shoulders that underwent anatomical total shoulder arthroplasty (TSA) or humeral head replacement (HHR) with a single uncemented humeral stem from 2008 to 2018. The patients were 31 men and 69 women. The mean age at surgery was 72.9 years (range, 41-86 years). The patients were divided into three groups: especially, 25, 61, and 14 shoulders received TSA for primary osteoarthritis without rotator cuff tears (TSA group), HHR using an anatomical head with rotator cuff repair for cuff tear arthropathy (CTA) (HHR group), and HHR using a CTA head without rotator cuff repair (CTA group), respectively. Patients were monitored for a mean of 56 months (range, 12-98 months). The location of bone resorption was divided into seven zones as follows: zone 1, greater tuberosity; zone 2, lateral diaphysis; zone 3, lateral diaphysis beyond the deltoid tuberosity; zone 4, tip of the stem; zone 5, medial diaphysis beyond the deltoid tuberosity; zone 6, medial diaphysis; and zone 7, calcar region. The degree of bone resorption was classified from grade 0 to 4.ResultsBone resorption of grade 3 or higher was significantly more frequent at the greater tuberosity in the HHR and CTA groups (P < .001 and P < .001, respectively) than that in the TSA group. Grade 4 bone resorption was significantly more frequent in the CTA than that in the TSA and HHR groups in zone 1 (P = .016 and P = .041, respectively).ConclusionThe state of attachment of the rotator cuff to the greater tuberosity might affect bone resorption at the greater tuberosity, such as the greater tuberosity after shoulder arthroplasty. In cases of shoulder arthroplasty for arthropathy with rotator cuff tear, performing rotator cuff repair might prevent bone resorption.Level of evidenceLevel IV; Prognosis Study 相似文献
3.
4.
Gordon K. B. Saburov V. O. Koryakin S. N. Gulidov I. A. Fatkhudinov T. Kh. Arutyunyan I. V. Kaprin A. D. Solov’ev A. N. 《Bulletin of experimental biology and medicine》2022,173(2):281-285
Bulletin of Experimental Biology and Medicine - Fast neutron therapy, which previously has demonstrated effective results, but along with a large number of complications, can again be considered a... 相似文献
5.
Zyuz’kov G. N. Zhdanov V. V. Miroshnichenko L. A. Polyakova T. Yu. Stavrova L. A. Simanina E. V. Minakova M. Yu. Agafonov V. I. Churin A. A. 《Bulletin of experimental biology and medicine》2022,173(5):615-619
Bulletin of Experimental Biology and Medicine - The psychopharmacological effects of a stimulator of functions of progenitor cells of the nervous tissue STAT3 inhibitor (STAT3 Inhibitor XIV, LLL12)... 相似文献
6.
7.
Yevdulov O. V. Yevdulov D. V. Isabekova T. I. Aminov G. I. Aminova I. Yu. 《Biomedical engineering》2022,56(2):146-150
Biomedical Engineering - A mathematical model of a thermoelectric device for the treatment of whitlow by local hypothermia is discussed. The model is based on a solution of the heat conduction task... 相似文献
8.
Md Maksudul Alam Janmaris Marin Fermin Patrick T. Spiller Chaning Burnett Xiaohua Rong Tara Moore-Medlin Caden O. Maxwell Alok R. Khandelwal Cherie-Ann O. Nathan 《Molecular carcinogenesis》2022,61(1):33-44
TP53 is the most frequently mutated gene in head and neck squamous cell carcinoma (HNSCC). Patients with HPV-negative TP53 mutant HNSCC have the worst prognosis, necessitating additional agents for treatment. Since mutant p53 causes sustained activation of the PI3K/AKT/mTOR signaling pathway, we investigated the effect of rapalogs RAD001 and CCI-779 on HPV-negative mutTP53 HNSCC cell lines and xenografts. Rapalogs significantly reduced cell viability and colony formation. Interestingly, rapalogs-induced autophagy with no effect on apoptosis. Pretreatment with autophagy inhibitors, 3-methyladenine (3-MA) and ULK-101 rescued the cell viability by inhibiting rapalog-induced autophagy, suggesting that both RAD001 and CCI-779 induce non-apoptotic autophagy-dependent cell death (ADCD). Moreover, rapalogs upregulated the levels of ULK1 and pULK1 S555 with concomitant downregulation of the mTORC1 pathway. However, pretreatment of cells with rapalogs prevented the ULK-101-mediated inhibition of ULK1 to sustained autophagy, suggesting that rapalogs induce ADCD through the activation of ULK1. To further translate our in vitro studies, we investigated the effect of RAD001 in HPV-negative mutTP53 (HN31 and FaDu) tumor cell xenograft model in nude mice. Mice treated with RAD001 exhibited a significant tumor volume reduction without induction of apoptosis, and with a concomitant increase in autophagy. Further, treatment with RAD001 was associated with a considerable increase in pULK1 S555 and ULK1 levels through the inhibition of mTORC1. 3-MA reversed the effect of RAD001 on FaDu tumor growth suggesting that RAD001 promotes ACDC in HPV-negative mutTP53 xenograft. This is the first report demonstrating that rapalogs promote non-apoptotic ADCD in HPV-negative mutTP53 HNSCC via the ULK1 pathway. Further studies are required to establish the promising role of rapalogs in preventing the regrowth of HPV-negative mutTP53 HNSCC. 相似文献
9.
Paulmurugan Ramasamy Malhotra Meenakshi Massoud Zahra T. Massoud Tarik F. 《Journal of molecular medicine (Berlin, Germany)》2022,100(7):1093-1093
Journal of Molecular Medicine - 相似文献
10.